Histones: Sequestered by Jabba in Fatty Storehouse
نویسندگان
چکیده
A paper in this issue shows that histones H2a and H2b are stored in lipid droplets in Drosophila embryos complexed with the protein Jabba. In Jabba mutant embryos, histones H2a and H2b are degraded but embryos survive by translating stored histone mRNA.
منابع مشابه
Lipid Droplets Control the Maternal Histone Supply of Drosophila Embryos
BACKGROUND Histones are essential for chromatin packing, yet free histones not incorporated into chromatin are toxic. While in most cells multiple regulatory mechanisms prevent accumulation of excess histones, early Drosophila embryos contain massive extranuclear histone stores, thought to be essential for development. Excess histones H2A, H2B, and H2Av are bound to lipid droplets, ubiquitous f...
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Assembly of DNA into chromatin requires a delicate balancing act, as both dearth and excess of histones severely disrupt chromatin function [1-3]. In particular, cells need to carefully control histone stoichiometry: if different types of histones are incorporated into chromatin in an imbalanced manner, it can lead to altered gene expression, mitotic errors, and death [4-6]. Both the balance be...
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The interaction of sodium n-dodecyl sulphate (SDS) with histones in phosphate buffer pH 6.4 has been studied spectroscopically and by equilibrium dialysis. The enthalpies of interaction and the spectroscopic data suggest different structural stability for histones-SDS interaction. The linear relation between enthaly and absorbtion was determined by the equation of m= , where m is the sta...
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2-Oxoglutarate (2OG) dependent dioxygenases are ubiquitous iron containing enzymes that couple substrate oxidation to the conversion of 2OG to succinate and carbon dioxide. They participate in a wide range of biological processes including collagen biosynthesis, fatty acid metabolism, hypoxic sensing and demethylation of nucleic acids and histones. Although substantial progress has been made in...
متن کاملChromatin assembly on replicating DNA in vitro.
Replicating single-stranded DNA is preferentially assembled into chromatin in Xenopus egg extracts relative to non-replicating double-stranded DNA. We have examined the molecular basis of this phenomenon. Single-stranded DNA itself is not a favored template for nucleosome assembly in comparison to double-stranded DNA. Complementary strand synthesis is required for the rapid assembly of nucleoso...
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عنوان ژورنال:
- Current Biology
دوره 22 شماره
صفحات -
تاریخ انتشار 2012